There is a question you don't hear everyday. Can mice live in your bed? Well let's think about this for a minute. Mice love fluffy, soft nesting material, they love warmth, they also love food and water. A bed can be all those things to a mouse if you are the kind of person who like to nibble in bed at night and watch television.
Mice are opportunistic and very curious. A box spring or eve a mattress can provide a perfect home for a family of mice. I think before they would move in though they would have to have explored the rest of your home. Chances are, if you have mice living in your bed then you have a bigger problem than just the mice living in your bed. I would think that the infestation of mice has gotten so bad that mice had to leave the areas in the kitchen do to over crowding. They had to look for another frontier. This new world would be the upstairs and your bed is their cabin.
So if you suspect mice in your bed then I would recommend first calling a qualified pest control company to come in and do a complete inspection and make some good recommendation for control.